It is impossible to get to 4000 Islands from Pakse which is easily accessible by bus from other parts of the country as well as from Thailand.
Upon arrival in Pakse, you could transfer to the small town of Muong Khong Town (island of Don Khong) or to Ban Nakasong Town (entrance town to Don Det and Don Khon islands).
There are 2 Ways to Get from Pakse to the 4000 Islands
Tourist Bus: From Pakse, tourist bus runs in the morning (around 8 or 9 am) to Don Khong and Don Det with the cost of around 60,000 Kip ($7.49). The ticket includes a bus and boat combination.
Local Transportation: You could also take the local transportation (pickup truck) if you want the more local adventurous route or if you could not depart in the morning. The pickup truck will take you to either Muong Khong Town or Ban Nakasong Town. It takes about 3 hours and costs 35,000 Kip ($4.37). After reaching Ban Nakasong, you need to hire a boat with the cost of 15,000 Kip ($1.87) to get to Don Det island.
